Recent Publications:

Since its inception, scientists at the Centre for Molecular Biology and Medicine have published more than 1000 papers in scientific journals. In spite of the recent relocations to temporary quarters at the Austin & Repatriation Hospital campus and subsequently to the Epworth Medical Centre, the Centre staff maintained a strong publication record.

1999

Dolgacheva L.P., Galitovskaya E.N., Zinchenko V.P. and Bronnikov G.E. "Reduction of the Ca2+-transporting systems in freshly isolated mouse brown preadipocytes" Biological Membranes (Moscow), 16, 410-415 (1999).

Gingold E.B., and Linnane A.W. "Coenzyme Q10 and its putative role in the ageing process" Protoplasma (in press 1999).

Rosenfeldt F.L., Pepe S., Ou R., Mariani J.A., Rowland M.A., Nagley P., Linnane A.W. "Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in human atrial tissue" BioFactors, 9, 291-299 (1999).

Rotaru V., Lajoie-Mazenc I., Tollon Y., Raynaud-Messina B., Jean C., Detraves C., Julian M., Moisand A., Wright M. "Condensation-decondensation of the g-tubulin containing material in the absence of a structurally visible organelle during the cell cycle of Physarum plasmodia" Biology of the Cell, 91, 393-406 (1999).

1998

Bronnikov G.E. and Vinogradova S.O. "Oscillatory regime of the ATP synthesis reaction catalysed by the F1Fo-ATPase of submitochondrial particles" BioThermoKinetics In The Post Genomic Era, ed. by Larsson C., Pahlman I.-L., Gustafsson L., 8, 231-235, Chalmer Reproservice, Göteborg (1998).

Bronnikov G. E., Vinogradova S. O. "Could the turnover-dependent inactivation of the F1Fo-ATPsynthase in oxidative phosphorylation be a reason for energy decline in vivo?" A Satellite Meeting of the IX International Congress on Neuromuscular Diseases (1998).

Bronnikov G.E., Kramarova L.I., Dolgacheva L.P., Zhang S.-J., Galitovskaya E.N. and Zinchenko V.P. "Neuropeptides kyotorphin and neokyotorphin affect proliferation of cultured brown preadipocytes via slow Ca2+-signalling system" Combined Conference of the Australian Society for Biochemistry and Molecular Biology and Australian Society of Plant Physiologists (1998).

Chisholm J., Hibbs A.R., Richardson M. and Linnane A.W. "Confocal microscopic analysis of the heterogeneity of expression of both mitochondrially and nuclearly encoded subunits of cytochrome c oxidase in fibers of aged human quadriceps muscle" Combined Conference of the Australian Society for Biochemistry and Molecular Biology and Australian Society of Plant Physiologists (1998).

Fitzpatrick J., Hibbs A.R., Kovalenko S.A., Kopsidas G., Caragounis A. and Linnane A.W. "The accumulation of mtDNA mutations in aged human skeletal muscle is independent of fibre type" A Satellite Meeting of the IX International Congress on Neuromuscular Diseases (1998).

Fitzpatrick J., Hibbs A.R., Kovalenko S., Kopsidas G., Caragounis A. and Linnane. A.W. "Bioenergy decline of aged human skeletal muscle is due to the accumulation of mtDNA mutations and is independent of fiber type" Combined Conference of the Australian Society for Biochemistry and Molecular Biology and Australian Society of Plant Physiologists (1998).

Gingold E., Kovalenko S.A., Kopsidas G., Addessi C.L., Islam M., Fitzpatrick J., Kayakawa M., Rosenfeldt F. and Linnane A.W. "A link between mtDNA rearrangements and the bioenergetic capacity of cardiac tissue from aged subjects" A Satellite Meeting of the IX International Congress on Neuromuscular Diseases (1998).

Hibbs A.R., Chisholm J., Stojanovski D., Richardson M. and Linnane A.W. "Heterogeneity between fibers of aged human quadriceps muscle in the expression of both mitochondrially and nuclearly encoded subunits of cytochrome c oxidase : A confocal microscopic analysis" A Satellite Meeting of the IX International Congress on Neuromuscular Diseases (1998).

Kopsidas G., Kovalenko S.A., Islam M., Fitzpatrick J., Caragounis A., Richardson M., Gingold E.B. and Linnane A.W. (1998). "Bioenergy and the ageing process: an age-associated reduction in cytochrome c oxidase activity in four different human skeletal muscles correlates with extensive mitochondrial DNA changes" A Satellite Meeting of the IX International Congress on Neuromuscular Disease (1998).

Kopsidas G., Kovalenko S.A., Kelso J.M., and Linnane A.W. "Age associated bioenergy degradation: A definitive correlation between cellular bioenergy decline and extensive mtDNA rearrangements in human skeletal muscle" Mutation Research, 421, 27-36 (1998).

Kovalenko S.A., Kopsidas G., Islam M., Fitzpatrick J., Gingold E. and Linnane A.W. "The age-associated decrease of the amount of functional mitochondrial DNA in human skeletal muscle" Biochemistry and Molecular Biology International, 46, No 6, 1233-1241 (1998).

Kovalenko S.A., Kopsidas G., Kelso J., Rosenfeldt F.L., and Linnane A.W. "Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human ageing" Annals N.Y. Academy of Science, 854, 171-181 (1998).

Linnane A.W., Kovalenko S.A. and Gingold E.B. "The universality of intrinsic bioenergetic disease: causation and potential amelioration therapy, Coenzyme Q10" First Conference of the International Coenzyme Q10 Association, Boston (1998).

Linnane A.W., Kovalenko S.A., and Gingold E.B. "The universality of bioenergetic disease: Age associated cellular bioenergetic degradation and amelioration therapy" Annals N.Y. Academy of Science, 854, 202-213 (1998).

Linnane A.W., Kovalenko S., Kopsidas G., Thomas T.M., Bronnikov G., Hibbs A.R., Fitzpatrick J., Richardson M. and Gingold E.B. "The universality of mitochondrial bioenergetic tissue decline: A definitive correlation between bioenergy decline and extensive mtDNA rearrangements" Proceedings of The Alfred Benzon Symposium No. 44 on Molecular Biology of Ageing¸ Copenhagen, Denmark, 335-345 (1998).

Linnane A.W., Kovalenko S., Kopsidas G., Thomas T.M., Bronnikov G., Hibbs A.R., Fitzpatrick J. and Gingold E.B. "Methods". Australian Provisional Patent (1998).

Rowland M.A., Nagley P., Linnane A.W., and Rosenfeldt F.L. "Coenzyme Q10 treatment improves the tolerance of the senescent myocardium to pacing stress in the rat" Cardiovascular Research, 40, 165-193 (1998).

Sababetis E., Vafiadis A. and Linnane A.W. SIM-4D3, "A serum diagnostic test for the improved detection and monitoring of gastrointestinal cancers" Australian Gastroenterology Meeting (1998).

Troop T., Grozdanovski D. and Potter I.C. "Natriuretic peptide binding sites in the gills of the pouched lamprey Geotria Auustralis" J. Exp. Biol. 201, 1799-1808 (1998).

Vallian S., Gaken J.A., Gingold E.B., Kouzarides T., Chang K.S. and Frazaneh F. "Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia protein" Oncogene 16, 2843-53 (1998).

Wraight C., Liepe I., White P., Hibbs A.R. and Worther G. "Intranuclear localisation of insulin-like growth factor binding protein-3 (IGFBP-3) during cell division in human keratinocytes" J. Investigative Dermatol 111, 239-242 (1998).

1997

Bronnikov G. E., Dolgacheva L. P., Zhang, S.-J., Kramarova L. I., Galitovskaya E. and Zinchenko V. P. (1997). The effect of neuropeptides kyotorphin and neokyotorphin on proliferation of cultured brown adipocytes. FEBS Letters 407:73-77.

Helfenbaum L., Ngo A., Ghelli A., Linnane A.W., and Degli Esposti M. (1997).  Proton pumping of mitochondrial complex I: differential activation by analogs of ubiquinone.  Journal of Bioenergetics and Biomembranes, 29: 71-80.

Hibbs A.R., Stenzel D.J. and Saul A.J. (1997). Macromolecular transport in malaria - Does the duct exist? European Journal of Cell Biology, 72:182-188.

Kovalenko S.A., Harms P.J., Tanaka M., Baumer A., Kelso J., Ozawa T., and Linnane A.W. (1997).  Method for in situ investigation of mitochondrial DNA deletions.  Human Mutation, 10:489-495.

Kovalenko S.A., Kopsidas G., Kelso J.M., and Linnane A.W. (1997).  Deltoid human muscle mtDNA is extensively rearranged in old age subjects.  Biochemical and Biophysical Research Communications Journal, 232: 147-152.

Koivisto A., Matthias A., Bronnikov G., and Nedergaard J. (1997) Kinetics of the inhibition of mitochondrial respiration by NO. FEBS Letters, 417: 75-80.

Kun J.F., Hibbs A.R., Saul A., McColl D.J., Coppel R.L. and Anders R. (1997). A putative Plasmodium falciparum exported serine/threonine protein kinase (FEST). Molecular & Biochemical Parasitology, 85:41-51.

La Greca N., Hibbs A.R., Riffkin C., Foley M. and Tilley L. (1997). Identification of an endoplasmic reticulum-resident calcium-binding protein with multiple EF-hand motifs in asexual stages of Plasmodium falciparum. Molecular & Biochemical Parasitology, 89:283-293.

Linnane A.W., Kopsidas G., Kelso J., and Kovalenko S.A. (1997).  Occurrence of age-associated multiple mtDNA rearrangements in human skeletal muscle.  Federation of American Societies for Experimental Biology Journal.

Liu V.W.S., Zhang C., Linnane A.W., and Nagley P. (1997).  Quantitative allele-specific PCR: Demonstration of age-associated accumulation in human tissues of the A®G mutation at nucleotide 3243 in mitochondrial DNA.  Human Mutation, 9 :265-271.

Vallian S., Gaken J.A., Trayner I.D., Gingold E.B., Kouzarides T., Chang K.S. and Frazaneh F. (1997). Transcriptional repression by the promyelocytic leukemia protein, PML. Exp. Cell Res. 237:371-82.

Zhang C., Bills M., Quigley A., Maxwell R.J., Linnane A.W., and Nagley P. (1997).  Varied prevalence of age-associated mitochondrial DNA deletions in different species and tissues: A comparison between human and rat.  Biochemical and Biophysical Research Communications, 230 :630-635.

Zhang C., Liu V.W.S., Addessi C.L., Sheffield D.A., Linnane A.W., and Nagley P. (1997).  Differential occurrence of mutations in mitochondrial DNA of human skeletal muscle during aging,  Human Mutation 11 :360-371.